Phenylpiperazine derivatives with strong affinity for 5HT 1A, D 2A and D 3 receptors

C Terán, L Santana, E Uriarte, Y Fall, L Unelius…

文献索引：Teran, Carmen; Santana, Lourdes; Uriarte, Eugenio; Fall, Yagamare; Unelius, Lena; Tolf, Bo-Ragnar Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 24 p. 3567 - 3570

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被引用次数: 23

摘要

Four 7-[3-(4-phenyl-1-piperazinyl) propoxy] coumarins were synthesized. The affinities of these compounds for DA (D2A, D3) and 5HT1A receptors were evaluated for their ability to displace [3H]-raclopride and [3H]-8-OH-DPAT respectively from their specific binding sites. The affinities of the target compounds were all in the nanomolar range and followed the order 5-HT1A> D2> D3.