Vitamin E metabolites: Synthesis of [D2]??and [D3]?螃摸?CEHC

F Mazzini, F Galli, P Salvadori

文献索引：Mazzini, Francesco; Galli, Francesco; Salvadori, Piero European Journal of Organic Chemistry, 2006 , # 24 p. 5588 - 5593

全文：HTML全文

被引用次数: 8

摘要

Abstract Deuterated analogues of α-and γ-CEHC, main urinary and plasma metabolites of vitamin E, can be traced and accurately determined quantitatively by MS in complex matrices. In that regard, here we report the first synthesis of rac-[D 3]-γ-CEHC together with a simple route to 7a, 8a-[D 2]-γ-CEHC through the set up of efficient procedures for the preparation of the corresponding deuterated hydroquinone building blocks.(© Wiley-VCH ...