A Direct, Regioselective Palladium??Catalyzed Synthesis of N??Substituted Benzimidazoles and Imidazopyridines

J Alonso, N Halland, M Nazare, O R'kyek…

文献索引：Alonso, Jorge; Halland, Nis; Nazare, Marc; R'Kyek, Omar; Urmann, Matthias; Lindenschmidt, Andreas European Journal of Organic Chemistry, 2011 , # 2 p. 234 - 237

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被引用次数: 15

摘要

Abstract Unsymmetric, N-substituted benzimidazoles and imidazopyridines can be prepared directly from 2-halonitroarenes and amides through Pd (TFA) 2/(R)-BINAP-catalyzed cross- coupling and subsequent reductive aminocyclization. This sequence can be conducted by a one-pot procedure. The method is versatile and allows the straightforward, regioselective preparation of these important nitrogen heterocycles.