Molecules

Mg2+-Imidazole-Catalyzed Self-Condensation of Malonyl Thioesters: Getting Tuned for Biomimetic Polyketide Synthesis?

N Sakai, N Sordé, S Matile

文献索引：Sakai, Naomi; Sorde, Nathalie; Matile, Stefan Molecules, 2001 , vol. 6, # 11 p. 845 - 851

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被引用次数: 19

摘要

Abstract: We report that a subtle balance of carbanion reactivity, leaving group activation, and p K a of the catalyst is required for efficient self-condensation of thiomalonates to thioacetoacetates in up to 71% yield under “biomimetic” conditions originally proposed by Kobuke and Yoshida (Tetrahedron Lett. 1978, 19, 367).