Structure??Guided Directed Evolution of Alkenyl and Arylmalonate Decarboxylases

…, M Wilding, M Goodall, N Baudendistel…

文献索引：Okrasa, Krzysztof; Wilding, Matthew; Goodall, Mark; Micklefield, Jason; Levy, Colin; Leys, David; Baudendistel, Nina; Hauer, Bernhard Angewandte Chemie, International Edition, 2009 , vol. 48, # 41 p. 7691 - 7694

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被引用次数: 48

摘要

The asymmetric decarboxylation of prochiral α-disubstituted malonic acids is an attractive route to produce homochiral αsubstituted carboxylic acids. Various metal-catalysed and organocatalytic methods have been explored for related enantioselective decarboxylative protonation (EDP) reactions.[1] However, the synthetic EDP methods can only deliver chiral carboxylic acids or esters with moderate enantioselectivities (ee).[1] On the other hand, ...