Bromophenols as Candida albicans isocitrate lyase inhibitors

…, YJ Lee, J Park, SH Lee, D Yang, M Kwon…

文献索引：Oh, Ki-Bong; Jeon, Heung Bae; Han, Yu-Ri; Lee, Yeon-Ju; Park, Jiyoung; Lee, So-Hyoung; Yang, Dongsik; Kwon, Mihyun; Shin, Jongheon; Lee, Hyi-Seung Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 22 p. 6644 - 6648

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被引用次数: 18

摘要

A new series of bromophenols was synthesized by reactions of corresponding phenol analogs with bromine. The synthesized compounds were tested for inhibitory activity against isocitrate lyase (ICL) of Candida albicans and antimicrobial activity against Gram-positive and, Gram-negative bacteria and fungi. Among the synthesized bromophenols, bis (3-bromo- 4, 5-dihydroxyphenyl) methanone (11) and (3-bromo-4, 5-dihydroxyphenyl)(2, 3-dibromo- ...