Hypoglycemic activity of 1-alkenyl-and 1-alkenoyl-3-arylsulfonylureas

G Pala, A Mantegani, A Omodei-Sale…

文献索引：Pala,G. et al. Journal of Medicinal Chemistry, 1970 , vol. 13, # 3 p. 556 - 557

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被引用次数: 3

摘要

An examination of the relative hypoglycemic potencies revealed that, among all the tested substances, only 1 was found to display an activity of some interest. This compound was then tested also orally in fasting rabbits as well as in normally fed rats and rabbits; the values for relative potency were 0.63, 0.85, and 0.41, respectively. From these findings, the conclusion may be drawn that 1 [1-(3-methyl-2-butenyl)-3-ptolylsulfonylurea] possesses ...