Il Farmaco

Synthesis and biological evaluation of new amino acids structurally related to the antitumor agent acivicin

P Conti, G Roda, H Stabile, MA Vanoni, B Curti…

文献索引：Conti, Paola; Roda, Gabriella; Stabile, Helena; Vanoni, Maria Antonietta; Curti, Bruno; De Amici, Marco Farmaco, 2003 , vol. 58, # 9 p. 683 - 690

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被引用次数: 11

摘要

A set of racemic conformationally constrained analogues of the antitumor antibiotic acivicin (+)-1 has been prepared through a strategy based on 1, 3-dipolar cycloaddition of bromonitrile oxide to suitable dipolarophiles. The bromo analogue (2) of acivicin was also synthesized and tested as a reference compound, together with its stereoisomer 3. The antitumor properties of novel amino acids 4–7 were evaluated in vitro against human ...