Palladium??Catalyzed Amidation by Chemoselective C (sp3) H Activation: Concise Route to Oxindoles Using a Carbamoyl Chloride Precursor

…, M Okuno, Y Takemoto

文献索引：Tsukano, Chihiro; Okuno, Masataka; Takemoto, Yoshiji Angewandte Chemie - International Edition, 2012 , vol. 51, # 11 p. 2763 - 2766

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被引用次数: 42

摘要

As oxindole forms the core of many complex natural products and is an important pharmacophore, its structure has attracted attention for over a century.[1] The oxindole structure has been constructed by the formation of a lactam from aniline,[1a] Wolff–Kishner- like reduction of isatin,[1b] oxidation of indole,[1c] transition metal catalyzed intramolecular amidation,[1d–f] and the Heck reaction.[1g, h] However, a concise method is still required ...