Potential antipsychotic agents. 5. Synthesis and antidopaminergic properties of substituted 5, 6-dimethoxysalicylamides and related compounds

…, S Bengtsson, T De Paulis, L Johansson…

文献索引：Hoegberg, Thomas; Bengtsson, Stefan; Paulis, Tomas de; Johansson, Lars; Stroem, Peter; et al. Journal of Medicinal Chemistry, 1990 , vol. 33, # 4 p. 1155 - 1163

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被引用次数: 32

摘要

EtOH. 5-10" C;(f) AlC13, CZHSCOCl, CHzClz, 10" C;(9) Hz, PdjC 570, emission tomography studies with [" Clraclopride indicate that the therapeutic action of a number of classical and atypical antipsychotic drugs is related to a substantial occupancy of dopamine-D2 re~ ept0rs. l~ The quantitative structure-activity relationships (QSAR) of the substituted salicylamides showed that the lipophilicity and steric bulk of the 3-substituent mainly ...