New benzocycloalkylpiperazines, potent and selective 5-HT1A receptor ligands

Y El Ahmad, E Laurent, P Maillet, A Talab…

文献索引：Ahmad, Youssef El; Laurent, Elisabeth; Maillet, Philippe; Talab, Akram; Teste, Jean Francois; Dokhan, Raymond; Tran, Gilles; Ollivier, Roland Journal of Medicinal Chemistry, 1997 , vol. 40, # 6 p. 952 - 960

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被引用次数: 12

摘要

A series of 1-(benzocycloalkyl)-4-(benzamidoalkyl) piperazine derivatives was prepared in order to obtain compounds with a high affinity and selectivity for 5-HT1A receptors. The modifications of aromatic substituents, the length of the alkyl chain, and the size of the ring were explored. Most of N-(1, 2, 3, 4-tetrahydronaphthyl)-N'-(benzamidoethyl) piperazines (32-37) were bound to 5-HT1A receptors in a nanomolar range and presented a high ...