Suzuki-Miyaura, α-ketone arylation and dehalogenation reactions catalyzed by a versatile N-heterocyclic carbene-palladacycle complex

O Navarro, N Marion, Y Oonishi, RA Kelly…

文献索引：Navarro, Oscar; Marion, Nicolas; Oonishi, Yoshihiro; Kelly III, Roy A.; Nolan, Steven P. Journal of Organic Chemistry, 2006 , vol. 71, # 2 p. 685 - 692

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被引用次数: 221

摘要

The activity of the complex (IPr) PdCl (η2-N, C-C12H7NMe2), 1 [IPr=(N, N'-bis (2, 6- diisopropylphenyl) imidazol)-2-ylidene], in the Suzuki-Miyaura cross-coupling reaction involving unactivated aryl chlorides and triflates with arylboronic acids at room temperature in technical grade 2-propanol is described. These conditions allow for the synthesis of di- and tri-ortho-substituted biaryls in very short reaction times. This complex also displays ...