An N??Heterocyclic Carbene Ligand with Flexible Steric Bulk Allows Suzuki Cross??Coupling of Sterically Hindered Aryl Chlorides at Room Temperature

G Altenhoff, R Goddard, CW Lehmann…

文献索引：Altenhoff, Gereon; Goddard, Richard; Lehmann, Christian W.; Glorius, Frank Angewandte Chemie - International Edition, 2003 , vol. 42, # 31 p. 3690 - 3693

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被引用次数: 384

摘要

The Suzuki cross-coupling reaction has become a standard method for biaryl synthesis in both academia and industry.[1] Its popularity is based on its wide functional-group tolerance and the ready availability and low toxicity of the required boronic acids. Although aryl iodides or bromides usually serve as the substrates, the development of new catalyst systems has recently enabled the efficient coupling of aryl chlorides, which are cheaper ...