Acetylcholinesterase inhibition by fused dihydroquinazoline compounds

…, VE Gregor, C Lee, R Davis, M Emmerling

文献索引：Jaen, Juan C.; Gregor, Vlad E.; Lee, Chet; Davis, Robert; Emmerling, Mark Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 6 p. 737 - 742

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被引用次数: 44

摘要

A new type of dihydroquinazoline-based inhibitor of acetylcholinesterase (AChE) is described. These compounds were designed to interact with the catalytic site of AChE in a manner similar to the known inhibitor tacrine. In a manner analogous to the potency enhancement obtained by addition of chlorine atoms to the tacrine molecule, a 3-chloro derivative of the parent hexahydroazepino [2, 1-b] quinazoline structure was found to be ...