Recently a series of amido and urea appended morpholines were disclosed as potent antagonists of CCR3. [1] These have potential therapeutic applications to asthma and rhinitis, and urea 1 is representative of this series. The chiral (dichloro)benzyl aminomethyl morpholine (2) was common to a number of these compounds (Scheme [1] ). ... The initial synthetic route to 2 proceeded with reaction of racemic epoxypropyl phthalimide (3) with dichlorobenzyl ethanolamine (4). ...
![2-{(2R)-3-[(3,4-dichlorobenzyl)(2-hydroxyethyl)amino]-2-hydroxypropyl}-1H-isoindole-1,3(2H)-dione结构式](https://image.chemsrc.com/caspic/135/610785-35-8.png)
![2-[4-(3,4-Dichloro-benzyl)-morpholin-2-ylmethyl]-isoindole-1,3-dione结构式](https://image.chemsrc.com/caspic/102/610305-43-6.png)
![2-{[4-(3,4-Dichlorobenzyl)-2-morpholinyl]methyl}-1H-isoindole-1,3 (2H)-dione结构式](https://image.chemsrc.com/caspic/070/407640-38-4.png)
