Studies on dihydropyridines. II. Synthesis of 4, 7-dihydropyrazolo (3, 4-b) pyridines with vasodilating and antihypertensive activities.

I ADACHI, T YAMAMORI, Y HIRAMATSU…

文献索引：Adachi; Yamamori; Hiramatsu; Sakai; Sato; Kawakami; Uno; Ueda Chemical and Pharmaceutical Bulletin, 1987 , vol. 35, # 8 p. 3235 - 3252

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被引用次数: 20

摘要

A series of 4-aryl-4, 7-dihydropyrazolo [3, 4-b] pyridine-5-carboxylate derivatives (72-149) was prepared and the compounds were tested for Ca-blocking activity in isolated guinea pig portal vein, antihypertensive activity in spontaneously hypertensive rats, and coronary vasodilating effect in isolated guinea pig heart. A number of derivatives had potent antihypertensive and coronary vasodilating activities. The structure-activity relationships of ...