Structure–activity relationships in the conversion of vitamin K analogues into menaquinone-4. Substrates essential to the synthesis of menaquinone-4 in cultured …

Y Suhara, A Wada, Y Tachibana, M Watanabe…

文献索引：Suhara, Yoshitomo; Wada, Akimori; Tachibana, Yoji; Watanabe, Masato; Nakamura, Kanae; Nakagawa, Kimie; Okano, Toshio Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 9 p. 3116 - 3124

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被引用次数: 7

摘要

To reveal an essential biological role of menaquinone-4, we have clarified that dietary PK was converted to menaquinone-4 (MK-4) in animal tissues using deuterated vitamin K analogues. However, the kinds of analogue converted into MK-4 have not been elucidated. In this study, we examined structure–activity relationships in the conversion of several vitamin K analogues, with a substituted side chain, into MK-4 using cultured human cell ...