Synthesis and in vivo evaluation of [11 C] MPTQ: a potential PET tracer for alpha2A-adrenergic receptors

…, L Savenkova, JJ Mann, RV Parsey, JSD Kumar

文献索引：Prabhakaran, Jaya; Majo, Vattoly J.; Milak, Matthew S.; Mali, Pratap; Savenkova, Lyudmila; Mann, J. John; Parsey, Ramin V.; Kumar, J.S. Dileep Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 12 p. 3654 - 3657

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被引用次数: 7

摘要

Radiosynthesis and in vivo evaluation of [N-methyl-11C] 5-methyl-3-[4-(3-phenylallyl)- piperazin-1-ylmethyl]-3, 3a, 4, 5-tetrahydroisoxazolo [4, 3-c] quinoline (1), a potential PET tracer for alpha2-adrenergic receptors is described. Syntheses of nonradioactive standard 1 and corresponding desmethyl precursor 2 were achieved from 2-aminobenzaldehyde in 40% and 65% yields, respectively. Methylation using [11C] CH3I in presence of aqueous ...