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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

3-Phenylpiperidines. Central dopamine-autoreceptor stimulating activity

U Hacksell, LE Arvidsson, U Svensson…

文献索引：Hacksell, Uli; Arvidsson, Lars-Erik; Svensson, Uno; Nilsson, J. Lars G. Journal of Medicinal Chemistry, 1981 , vol. 24, # 12 p. 1475 - 1482

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被引用次数: 94

摘要

Thirty compounds related to the selective dopamine-autoreceptor agonist 3-(3- hydroxyphenyl)-Nn-propylpiperidine have been synthesized and tested for central dopamineautoreceptor stimulating activity. The 3-(3-hydroxypheny1) piperidine moiety seems indispensable for high potency and selectivity. Introduction of an additional hydroxyl group into the 4 position of the aromatic ring gives a compound with dopaminergic activity ...

1-[3-(3,4-dimethoxyphenyl)piperidin-1-yl]propan-1-one结构式

1-[3-(3,4-dimet...

~%

3-(3,4-dimethoxyphenyl)-1-propylpiperidine结构式

3-(3,4-dimethox...

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3-溴吡啶结构式

~%

3-(3,4-dimethoxyphenyl)-1-propylpiperidine结构式

3-(3,4-dimethox...

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3-(3,4-Dimethoxyphenyl)pyridine结构式

3-(3,4-Dimethox...

~%

3-(3,4-dimethoxyphenyl)-1-propylpiperidine结构式

3-(3,4-dimethox...

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3-(3,4-dimethoxyphenyl)piperidine结构式

3-(3,4-dimethox...

~%

3-(3,4-dimethoxyphenyl)-1-propylpiperidine结构式

3-(3,4-dimethox...

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3-(3,4-dimethoxyphenyl)-1-propylpiperidine结构式

3-(3,4-dimethox...

~85%

4-(1-propylpiperidin-3-yl)benzene-1,2-diol,hydrobromide结构式

4-(1-propylpipe...

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3-溴吡啶结构式

~%

4-(1-propylpiperidin-3-yl)benzene-1,2-diol,hydrobromide结构式

4-(1-propylpipe...

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3,4-二甲氧基苯基溴化镁结构式

3,4-二甲氧基苯基溴化镁

~%

4-(1-propylpiperidin-3-yl)benzene-1,2-diol,hydrobromide结构式

4-(1-propylpipe...

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3-(3,4-Dimethoxyphenyl)pyridine结构式

3-(3,4-Dimethox...

~%

4-(1-propylpiperidin-3-yl)benzene-1,2-diol,hydrobromide结构式

4-(1-propylpipe...

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3-(3,4-dimethoxyphenyl)piperidine结构式

3-(3,4-dimethox...

~%

4-(1-propylpiperidin-3-yl)benzene-1,2-diol,hydrobromide结构式

4-(1-propylpipe...

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1-[3-(3,4-dimethoxyphenyl)piperidin-1-yl]propan-1-one结构式

1-[3-(3,4-dimet...

~%

4-(1-propylpiperidin-3-yl)benzene-1,2-diol,hydrobromide结构式

4-(1-propylpipe...

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3-溴吡啶结构式

~%

3-苯基哌啶结构式

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3-(4-甲氧基苯基)吡啶结构式

3-(4-甲氧基苯基)吡啶

~%

3-(4-甲氧基苯基)哌啶结构式

3-(4-甲氧基苯基)哌啶

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3-溴吡啶结构式

~%

3-(4-甲氧基苯基)哌啶结构式

3-(4-甲氧基苯基)哌啶

查看详情

4-甲氧基苯基溴化镁结构式

4-甲氧基苯基溴化镁

~%

3-(4-甲氧基苯基)哌啶结构式

3-(4-甲氧基苯基)哌啶

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3-(3,4-dimethoxyphenyl)piperidine结构式

3-(3,4-dimethox...

~70%

4-piperidin-3-ylbenzene-1,2-diol,hydrobromide结构式

4-piperidin-3-y...

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3-溴吡啶结构式

~%

4-piperidin-3-ylbenzene-1,2-diol,hydrobromide结构式

4-piperidin-3-y...

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3,4-二甲氧基苯基溴化镁结构式

3,4-二甲氧基苯基溴化镁

~%

4-piperidin-3-ylbenzene-1,2-diol,hydrobromide结构式

4-piperidin-3-y...

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3-(3,4-Dimethoxyphenyl)pyridine结构式

3-(3,4-Dimethox...

~%

4-piperidin-3-ylbenzene-1,2-diol,hydrobromide结构式

4-piperidin-3-y...

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3-溴吡啶结构式

~%

1-[3-(3,4-dimethoxyphenyl)piperidin-1-yl]propan-1-one结构式

1-[3-(3,4-dimet...

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3,4-二甲氧基苯基溴化镁结构式

3,4-二甲氧基苯基溴化镁

~%

1-[3-(3,4-dimethoxyphenyl)piperidin-1-yl]propan-1-one结构式

1-[3-(3,4-dimet...

查看详情

3-(3,4-Dimethoxyphenyl)pyridine结构式

3-(3,4-Dimethox...

~%

1-[3-(3,4-dimethoxyphenyl)piperidin-1-yl]propan-1-one结构式

1-[3-(3,4-dimet...

查看详情

3-(3,4-dimethoxyphenyl)piperidine结构式

3-(3,4-dimethox...

丙酰氯结构式

~%

1-[3-(3,4-dimethoxyphenyl)piperidin-1-yl]propan-1-one结构式

1-[3-(3,4-dimet...

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3-溴吡啶结构式

间甲苯基溴化镁结构式

间甲苯基溴化镁

~%

3-(3-Methylphenyl)pyridine结构式

3-(3-Methylphen...

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3-(3-Methylphenyl)pyridine结构式

3-(3-Methylphen...

~%

3-(3-甲苯基)哌啶结构式

3-(3-甲苯基)哌啶

查看详情

3-溴吡啶结构式

~%

3-(3-甲苯基)哌啶结构式

3-(3-甲苯基)哌啶

查看详情

间甲苯基溴化镁结构式

间甲苯基溴化镁

~%

3-(3-甲苯基)哌啶结构式

3-(3-甲苯基)哌啶

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3-溴吡啶结构式

3-氟苯基溴化镁结构式

3-氟苯基溴化镁

~%

3-(3-fluorophenyl)pyridine结构式

3-(3-fluorophen...

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3-(3,4-Dimethoxyphenyl)pyridine结构式

3-(3,4-Dimethox...

~%

3-(3,4-dimethoxyphenyl)piperidine结构式

3-(3,4-dimethox...

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3-溴吡啶结构式

~%

3-(3,4-dimethoxyphenyl)piperidine结构式

3-(3,4-dimethox...

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3,4-二甲氧基苯基溴化镁结构式

3,4-二甲氧基苯基溴化镁

~%

3-(3,4-dimethoxyphenyl)piperidine结构式

3-(3,4-dimethox...

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New synthesis of 3-aryl-Nn-propyl-piperidines

[Chang, Meng-Yang; Chen, Shui-Tein; Chang, Nein-Chen Tetrahedron, 2002 , vol. 58, # 18 p. 3623 - 3628]

New synthesis of 3-aryl-Nn-propyl-piperidines

[Chang, Meng-Yang; Chen, Shui-Tein; Chang, Nein-Chen Tetrahedron, 2002 , vol. 58, # 18 p. 3623 - 3628]

New synthesis of 3-aryl-Nn-propyl-piperidines

[Chang, Meng-Yang; Chen, Shui-Tein; Chang, Nein-Chen Tetrahedron, 2002 , vol. 58, # 18 p. 3623 - 3628]

New synthesis of 3-aryl-Nn-propyl-piperidines

[Chang, Meng-Yang; Chen, Shui-Tein; Chang, Nein-Chen Tetrahedron, 2002 , vol. 58, # 18 p. 3623 - 3628]

New synthesis of 3-aryl-Nn-propyl-piperidines

[Chang, Meng-Yang; Chen, Shui-Tein; Chang, Nein-Chen Tetrahedron, 2002 , vol. 58, # 18 p. 3623 - 3628]