Tetrahedron Letters

Synthesis of diarylmethane derivatives from Stille cross-coupling reactions of benzylic halides

TZ Nichele, AL Monteiro

文献索引：Nichele, Tatiana Z.; Monteiro, Adriano L. Tetrahedron Letters, 2007 , vol. 48, # 42 p. 7472 - 7475

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被引用次数: 24

摘要

A catalyst precursor prepared in situ from palladium acetate and a phosphine ligand was used for the Stille cross-coupling reaction of benzylic bromides and chlorides with aryltributyltin analogues. The reactions were performed at 80° C using dppf as ligand in the presence of KF, or more conveniently using PPh3 in the absence of base, furnishing diarylmethane derivatives in high yields (86–99%). Using Pd (OAc) 2/PPh3 as catalyst ...