Catalytic decomposition of simulants for chemical warfare V agents: highly efficient catalysis of the methanolysis of phosphonothioate esters

SA Melnychuk, AA Neverov…

文献索引：Melnychuk, Stephanie A.; Neverov, Alexei A.; Brown, R. Stan Angewandte Chemie - International Edition, 2006 , vol. 45, # 11 p. 1767 - 1770

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被引用次数: 36

摘要

Among the most noxious materials made by man are the organophosphorus chemical- warfare materials, such as the phosphonofluoridate G agents soman (1) and sarin (2) and the phosphonothioate V agents, such as VX (3).[2] The latter is particularly toxic [3] because it is N-protonated at physiological pH and is therefore well accommodated by the acetylcholine esterase active site, which it inhibits through irreversible phosphonyl transfer ...