2-(Aminomethyl) phenols, a new class of saluretic agents. 3. Effects of functional group reorientation and modification

GE Stokker, AA Deana, SJ DeSolms…

文献索引：Stokker, G. E.; Deana, A. A.; deSolms, S. J.; Schultz, E. M.; Smith, R. L.; et al. Journal of Medicinal Chemistry, 1981 , vol. 24, # 9 p. 1063 - 1067

全文：HTML全文

被引用次数: 1

摘要

A series of modified 2-(aminomethy1) phenols was synthesized and tested orally in rats for saluretic and diuretic effects. Intravenous dog data are included as supplementary material to show that the diuretic responses, or lack thereof, may be obtained in a second species. Reorientation of the 2-(aminomethyl) group either meta or para to the hydroxyl substituent resulted in loss of diuretic effects. Similarly, replacement of either the phenolic hydroxyl or ...