5-[4-(3, 3-Dimethylbutoxycarbonyl) phenyl]-4-pentynoic acid and its derivatives inhibit ionotropic γ-aminobutyric acid receptors by binding to the 4′-ethynyl-4-n- …

H Hamano, K Nagata, N Fukada, H Shimotahira…

文献索引：Hamano, Hiroshi; Nagata, Keiichi; Fukada, Nobuo; Shimotahira, Hiroshi; Ju, Xiu-Lian; Ozoe, Yoshihisa Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 3 p. 665 - 674

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被引用次数: 15

摘要

Acyclic noncompetitive antagonists of ionotropic γ-aminobutyric acid (GABA) receptors, bearing an ester or ether linkage, were designed, synthesized, and assayed for their inhibition of the specific binding of [3H] 4′-ethynyl-4-n-propylbicycloorthobenzoate (EBOB), a radiolabeled noncompetitive antagonist, to rat brain and housefly head membranes. 5-[4- (3, 3-Dimethylbutoxycarbonyl) phenyl]-4-pentynoic acid (DBCPP), a butyl benzoate ...