Construction of the Six??and Five??Membered Aza??Heterocyclic Units of the Isoindoloisoquinolone Nucleus by Parham??Type Cyclization Sequences–Total Synthesis of …

A Moreau, A Couture, E Deniau…

文献索引：Moreau, Anne; Couture, Axel; Deniau, Eric; Grandclaudon, Pierre European Journal of Organic Chemistry, 2005 , # 16 p. 3437 - 3442

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被引用次数: 22

摘要

Abstract An efficient methodology for the synthesis of isoindolo [1, 2-a] isoquinolones based on two Parham-type cyclizations allowing the formation of the five-and six-membered nitrogenated rings from carbamate or diacylamine precursors is described. The synthetic potential of this method has been further illustrated by the total synthesis of the alkaloid nuevamine.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)