Biochemistry

FT-ICR-MS characterization of intermediates in the biosynthesis of the α-methylbutyrate side chain of lovastatin by the 277 kDa polyketide synthase LovF

MJ Meehan, X Xie, X Zhao, W Xu, Y Tang…

文献索引：Amoroso, Jon W.; Borketey, Lawrence S.; Prasad, Gitanjeli; Schnarr, Nathan A. Organic Letters, 2010 , vol. 12, # 10 p. 2330 - 2333

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被引用次数: 10

摘要

... DOI: 10.1021/bi1014776. Publication Date (Web): November 11, 2010. Copyright © 2010 American Chemical Society. ... The resulting acetoacetyl-S-ACP undergoes MT-catalyzed C-methylation of the α-carbon. ... was digested using 1 μg of proteomic grade trypsin (1:200 w/w) ...