Tetrahedron Letters

A highly practical synthesis of natural PGE 1, Δ 2-trans-PGE 1 and 2, 2, 3, 3-tetradehydro-PGE 1 via two-component coupling process using zinc-copper reagents

H Tsujiyama, N Ono, T Yoshino, S Okamoto, F Sato

文献索引：Tsujiyama; Ono; Yoshino; Okamoto; Sato Tetrahedron Letters, 1990 , vol. 31, # 31 p. 4481 - 4484

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被引用次数: 30

摘要

Abstract A highly practical synthesis of natural PGE 1, Δ 2-trans-PGE 1 and 2, 2, 3, 3- tetradehydro-PGE 1 has been achieved in which the 1, 4-addition reaction of the corresponding functionalized zinc-copper reagents to the enones 2 and/or 4 plays a key role.