Synthesis of condensed quinolines and quinazolines as DNA ligands

…, JF Goossens, R Houssin, C Bailly, JP Hénichart

文献索引：Malecki, Natacha; Carato, Pascal; Rigo, Benoit; Goossens, Jean-Francois; Houssin, Raymond; Bailly, Christian; Henichart, Jean-Pierre Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 3 p. 641 - 647

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被引用次数: 70

摘要

Among new condensed quinolines and quinazolines the design of which were inspired by anti-cancer DNA-binding alkaloids such as camptothecin and batracyclin, DNA binding tests identify the 8-methoxy-7-piperazinylpropoxyindeno [1, 2-b] quinolin-11-one tetracyclic system as a new motif for DNA recognition.