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Synthesis and antitumor activity of new 1, 2, 4??triazine and [1, 2, 4] triazolo [4, 3??b][1, 2, 4] triazine derivatives and their thioglycoside and acyclic C??nucleoside …

…, IF Nassar, AAH Abdel??Rahman

文献索引:El-Sayed, Wael A.; Nassar, Ibrahim F.; Abdel-Rahman, Adel A.-H. Journal of Heterocyclic Chemistry, 2011 , vol. 48, # 1 p. 135 - 143

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被引用次数: 19

摘要

Abstract New 1, 2, 4-triazine and their derived 1, 2, 4-triazolo [3, 4-b][1, 2, 4] triazine derivatives were synthesized starting from 5, 6-diphenyl-1, 2, 4-triazine-3-thiol. Furthermore, the corresponding 1, 2, 4-triazolo [3, 4-b][1, 2, 4]-triazine thioglycosides and acyclic C- nucleoside analogs were synthesized. The newly synthesized compounds were evaluated for their antitumor activity and some of them showed high inhibition activities. J. ...