5-Alkylresorcinols from Hakea trifurcata, that cleave DNA.

…, VS Murty, KS Reddy, JR Barr, SM Hecht

文献索引：Lytollis, William; Scannell, Ralph T.; An, Haoyun; Murty; Reddy, K. Sambi; Barr, John R.; Hecht, Sidney M. Journal of the American Chemical Society, 1995 , vol. 117, # 51 p. 12683 - 12690

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被引用次数: 68

摘要

Abstract: A dichloromethane extract of Hakea trifurcata that mediated relaxation of 4x174 replicative form DNA at micromolar concentrations in the presence of Cu2+ was resolved into six active components by bioassay-guided fractionation. Five of the active principles were characterized structurally and shown to be 5-alkylresorcinol derivatives.