General reaction conditions for the synthesis of aryl (trialkoxy) silanes from aryl Grignard and lithium reagents and tetraalkyl orthosilicates (Si (OR) 4) have been developed. Ortho-, meta- , and para-substituted bromoarenes underwent efficient metalation and silylation at low temperature to provide aryl siloxanes. Mixed results were obtained with heteroaromatic substrates: 3-bromothiophene, 3-bromo-4-methoxypyridine, 5-bromoindole, and N-methyl ...
