Five lPD-arabinofuranosylcytosine conjugates and two cytidine conjugates of thioether lipids (1-S-alkylthioglycerolsj linked by a pyrophosphate diester bond have been prepared and their antitumor activity against an ara-C2 sensitive (L1210/0) and two ara-C resistant L1210 lymphoid leukemia sublines in mice were evaluated. These prodrugs of ara-C include ara- CDP-rac-lS-hexadecyl-2-0-palmitoyl-l-thioglycerol@ a), ara-CDP-rac-lS-octadecyl-2-0- ...
