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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Synthesis of 3-aminopyrazinone mediated by 2-pyridylthioimidate-ZnCl2 complexes. Development of an efficient route to a thrombin inhibitor

…, DJ Mathre, JR Chilenski, B Mao…

文献索引：Zhou, X.-X.; Welch, C.J.; Chattopadhyaya, J. Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1986 , vol. 40, # 10 p. 806 - 816

全文：HTML全文

被引用次数: 12

摘要

... The Journal of Organic Chemistry. ... Departments of Process Research and Department of Analytical Research, Merck Research Laboratories, PO Box 2000, Rahway, New Jersey 07065. J. Org. Chem. , 2003, 68 (23), pp 8838 ...

1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-((6-methylpyridin-3-yl)oxy)pyrimidin-2(1H)-one结构式

1-((2R,3R,4S,5R...

~%

(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(2-oxo-4-(pyridin-3-yloxy)pyrimidin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate结构式

(2R,3R,4R,5R)-2...

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1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(pyridin-2-ylthio)pyrimidin-2(1H)-one结构式

1-((2R,3R,4S,5R...

~%

(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(2-oxo-4-(pyridin-3-yloxy)pyrimidin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate结构式

(2R,3R,4R,5R)-2...

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1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(2-oxopyridin-1(2H)-yl)pyrimidin-2(1H)-one结构式

1-((2R,3R,4S,5R...

~%

(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(2-oxo-4-(pyridin-3-yloxy)pyrimidin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate结构式

(2R,3R,4R,5R)-2...

查看详情

1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(pyridin-3-yloxy)pyrimidin-2(1H)-one结构式

1-((2R,3R,4S,5R...

~%

(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(2-oxo-4-(pyridin-3-yloxy)pyrimidin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate结构式

(2R,3R,4R,5R)-2...

查看详情

1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-((6-methylpyridin-2-yl)oxy)pyrimidin-2(1H)-one结构式

1-((2R,3R,4S,5R...

~%

(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(2-oxo-4-(pyridin-3-yloxy)pyrimidin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate结构式

(2R,3R,4R,5R)-2...

查看详情

1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-((6-methylpyridin-3-yl)oxy)pyrimidin-2(1H)-one结构式

1-((2R,3R,4S,5R...

~%

2',3',5'-tri-O-acetyl-N4-methyl-cytidine结构式

2',3',5'-tri-O-...

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1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(pyridin-2-ylthio)pyrimidin-2(1H)-one结构式

1-((2R,3R,4S,5R...

~%

2',3',5'-tri-O-acetyl-N4-methyl-cytidine结构式

2',3',5'-tri-O-...

查看详情

1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(2-oxopyridin-1(2H)-yl)pyrimidin-2(1H)-one结构式

1-((2R,3R,4S,5R...

~%

2',3',5'-tri-O-acetyl-N4-methyl-cytidine结构式

2',3',5'-tri-O-...

查看详情

1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(pyridin-3-yloxy)pyrimidin-2(1H)-one结构式

1-((2R,3R,4S,5R...

~%

2',3',5'-tri-O-acetyl-N4-methyl-cytidine结构式

2',3',5'-tri-O-...

查看详情

1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-((6-methylpyridin-2-yl)oxy)pyrimidin-2(1H)-one结构式

1-((2R,3R,4S,5R...

~%

2',3',5'-tri-O-acetyl-N4-methyl-cytidine结构式

2',3',5'-tri-O-...

查看详情

吗啉结构式

(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(2-oxo-4-(pyridin-3-yloxy)pyrimidin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate结构式

(2R,3R,4R,5R)-2...

~92%

(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(4-morpholino-2-oxopyrimidin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate结构式

(2R,3R,4R,5R)-2...

查看详情

吗啉结构式

(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(4-((6-methylpyridin-3-yl)oxy)-2-oxopyrimidin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate结构式

(2R,3R,4R,5R)-2...

~93%

(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(4-morpholino-2-oxopyrimidin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate结构式

(2R,3R,4R,5R)-2...

查看详情

1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-((6-methylpyridin-3-yl)oxy)pyrimidin-2(1H)-one结构式

1-((2R,3R,4S,5R...

~%

(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(4-morpholino-2-oxopyrimidin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate结构式

(2R,3R,4R,5R)-2...

查看详情

1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(pyridin-2-ylthio)pyrimidin-2(1H)-one结构式

1-((2R,3R,4S,5R...

~%

(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(4-morpholino-2-oxopyrimidin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate结构式

(2R,3R,4R,5R)-2...

查看详情

1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-((6-methylpyridin-3-yl)oxy)pyrimidin-2(1H)-one结构式

1-((2R,3R,4S,5R...

~%

(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(4-((6-methylpyridin-3-yl)oxy)-2-oxopyrimidin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate结构式

(2R,3R,4R,5R)-2...

查看详情

1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(pyridin-2-ylthio)pyrimidin-2(1H)-one结构式

1-((2R,3R,4S,5R...

~%

(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(4-((6-methylpyridin-3-yl)oxy)-2-oxopyrimidin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate结构式

(2R,3R,4R,5R)-2...

查看详情

1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(2-oxopyridin-1(2H)-yl)pyrimidin-2(1H)-one结构式

1-((2R,3R,4S,5R...

~%

(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(4-((6-methylpyridin-3-yl)oxy)-2-oxopyrimidin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate结构式

(2R,3R,4R,5R)-2...

查看详情

1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(pyridin-3-yloxy)pyrimidin-2(1H)-one结构式

1-((2R,3R,4S,5R...

~%

(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(4-((6-methylpyridin-3-yl)oxy)-2-oxopyrimidin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate结构式

(2R,3R,4R,5R)-2...

查看详情

1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-((6-methylpyridin-2-yl)oxy)pyrimidin-2(1H)-one结构式

1-((2R,3R,4S,5R...

~%

(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(4-((6-methylpyridin-3-yl)oxy)-2-oxopyrimidin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate结构式

(2R,3R,4R,5R)-2...

查看详情