Chemical and pharmaceutical bulletin

Nucleosides. CXLIX. Novel and practical synthesis of. ALPHA.-monofluoro-and. ALPHA.,. ALPHA.-difluorothymidine (F-TDR and F2-TDR).

JM ADAMIC, KA WATANABE

文献索引：Matulic-Adamic; Watanabe Chemical and Pharmaceutical Bulletin, 1988 ,  vol. 36,  # 4  p. 1554 - 1557

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被引用次数: 6

摘要

Di-O-tert-butyldiphenylsilyl (BDPS)-thymidine (2) was converted to α-bromo-3', 5'-di-O-BDPS- thymidine (3) by photobromination. Crude 3 was hydrolyzed to the α-hydroxythymidine derivative 4 which was oxidized with MnO 2 to the 5-formyluracil nucleoside 5. Fluorination