The effect of glycosylation on the structure of designed four-helix bundle motifs

LK Andersson, GT Dolphin, J Kihlberg…

文献索引：Andersson, Linda K.; Dolphin, Gunnar T.; Kihlberg, Jan; Baltzer, Lars Journal of the Chemical Society. Perkin Transactions 2, 2000 , # 3 p. 459 - 464

全文：HTML全文

被引用次数: 23

摘要

A galactose-, 1, and a cellobiose derivative, 2, have been site selectively, post- translationally, incorporated into a folded helix-loop-helix dimer LA-42b in a one step reaction at room temperature. The structural effects on the folded peptide upon glycosylation have been studied by CD and NMR spectroscopy. The negative value of the mean residue ellipticity of the folded peptide, LA-42b, was raised from− 19000±1000 to− 21200±1000 ...