Synthesis of functionalized cannabinoids

…, IA Stergiades, J Erickson, A Makriyannis…

文献索引：Harrington, Paul E.; Stergiades, Ioanna A.; Erickson, Joy; Makriyannis, Alexandros; Tius, Marcus A. Journal of Organic Chemistry, 2000 , vol. 65, # 20 p. 6576 - 6582

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被引用次数: 42

摘要

Earlier efforts in our groups had revealed a correlation between the stereochemistry of the southern aliphatic hydroxyl (SAH) group, the chain length, and the affinity of the compounds for CB1 and CB2, the two known cannabinoid receptors, within a series of hybrid cannabinoids. 1 A systematic study, in which C6 stereochemistry and the chain length of the group appended to this carbon were varied, revealed that the C6β hydroxypropyl analogue had a high affinity for both ...