Tetrahedron letters

Total synthesis of cis and trans-hydroxyglimepiride: active metabolite of glimepiride

…, SR Chaudhuri, SV Joshi, AR Barde, LK Gediya…

文献索引：Gurjar, Mukund K.; Joshi, Ramesh A.; Chaudhuri, Siddhartha R.; Joshi, Shreerang V.; Barde, Anup R.; Gediya, Lalji K.; Ranade, Prasad V.; Kadam, Suresh M.; Naik, Sanjay J. Tetrahedron Letters, 2003 , vol. 44, # 26 p. 4853 - 4855

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被引用次数: 6

摘要

Among the sulfonylurea 1., and class of anti-diabetic drugs, glimepiride 2., and 1 has many distinctive advantages and is by far the most superior blood glucose lowering agent. 3 Its biological activity initiates with binding to the 65 KD protein of the putative receptor. In addition, glimepiride shows a three-fold faster rate of association and a nine-fold faster rate of dissociation than glibenclamide, 1., and which permitted its use as a once daily administration drug. 4 ...