Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 1

M Masubuchi, K Kawasaki, H Ebiike, Y Ikeda…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 14 p. 1833 - 1837

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被引用次数: 89

摘要

... Bioorganic & Medicinal Chemistry Letters. ... 10 Thus we initiated the chemical modification study of 1 to identify a highly potent and safe antifungal agent by improving the enzyme inhibitory activity while eliminating the β-blocking action (IC 50 : 0.098 μM). Synthesis. ...