Synthesis of four diastereomeric L-2-(carboxycyclopropyl) glycines. Conformationally constrained L-glutamate analogs

K Shimamoto, M Ishida, H Shinozaki…

文献索引：Shimamoto, Keiko; Ishida, Michiko; Shinozaki, Haruhikio; Ohfune, Yasufumi Journal of Organic Chemistry, 1991 , vol. 56, # 13 p. 4167 - 4176

全文：HTML全文

被引用次数: 178

摘要

To determine what conformations of L-glutamate (LG~ u) activate that compound's different receptors in the mammalian central nervous system, four diastereomeric L-2- (carboxycyclopropyl) glycines, 1-4, which are conformationally conetrainsd aualogues of the extended and folded conformers of LGlu, were synthesized and subjected to neutrophysiological amy. Compounds 1-4 were efficiently synthesized from chiral amino ...