Diisopropylethylamine mono (hydrogen fluoride) for nucleophilic fluorination of sensitive substrates: synthesis of sevoflurane

…, RA Lessor, LA Rozov, S Afrin, C McCutcheon…

文献索引：Kudzma; Huang; Lessor; Rozov; Afrin; Kallashi; McCutcheon; Ramig Journal of Fluorine Chemistry, 2001 , vol. 111, # 1 p. 11 - 16

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被引用次数: 11

摘要

Diisopropylethylamine mono (hydrogen fluoride)(8), which can be prepared by addition of two equivalents of diisopropylethylamine to the complex diisopropylethylamine tris (hydrogen fluoride)(7), is shown to be an effective and selective nucleophilic fluorinating reagent when applied to halogen-exchange reactions of chloromethyl ethers, in particular the conversion of 1, 1, 1, 3, 3, 3-hexafluoroisopropyl chloromethyl ether (3) to the volatile ...