Carbocyclic analogs of thymine nucleosides and related 1??substituted thymines

YF Shealy, CA O'Dell, MC Thorpe

文献索引：Shealy, Y.Fulmer; O'Dell, C.Allen; Thorpe, Martha C. Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 383 - 389

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被引用次数: 66

摘要

Abstract The carbocyclic analogs of thymidine (IXf), 1-β-ribofuranosylthymine (IXg), and 1-β- 3′-deoxyribofuranosyl-thymine (IXe) were synthesized by incorporating modifications into the Shaw method of synthesizing 2, 4-(1H, 3H) pyrimidinediones via acryloylureas. Simpler analogs of thymine nucleosides were also prepared by this method. The carbocyclic analog of thymidine displayed modest activity against Leukemia L1210 in vivo. It differs from a ...