Synthesis and pharmacological evaluation of new cysLT 1 receptor antagonists

…, M Armengol, A Reyes, M Alvarez, A Palomer…

文献索引：Griera; Armengol; Reyes; Alvarez; Palomer; Cabre; Pascual; Garcia; Mauleon European Journal of Medicinal Chemistry, 1997 , vol. 32, # 7-8 p. 547 - 570

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被引用次数: 14

摘要

This paper describes the synthesis and pharmacological evaluation of three series of compounds 4a–b, 13a–k and 19, structurally related to the known potent cysLT1 receptor antagonists RG-12553, ICI-204219 and ONO-1078, respectively. The common structural feature of these new series is the presence of a 4-quinolone nucleus acting as a template for substitution of the aromatic nucleus present in the prototype antagonists. We describe the ...