In vivo anti-Chagas vinylthio-, vinylsulfinyl-, and vinylsulfonylbenzofuroxan derivatives

…, A Castro, RL Krauth-Siegel, C Davies…

文献索引：Porcal, Williams; Hernandez, Paola; Boiani, Mariana; Aguirre, Gabriela; Boiani, Lucia; Chidichimo, Agustina; Cazzulo, Juan J.; Campillo, Nuria E.; Paez, Juan A.; Castro, Ana; Krauth-Siegel, R. Luise; Davies, Carolina; Basombrio, Miguel Angel; Gonzalez, Mercedes; Cerecetto, Hugo Journal of Medicinal Chemistry, 2007 , vol. 50, # 24 p. 6004 - 6015

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被引用次数: 30

摘要

New benzofuroxans were developed and studied as antiproliferative Trypanosoma cruzi agents. Compounds displayed remarkable in vitro activities against different strains, Tulahuen 2, CL Brener and Y. Its unspecific cytotoxicity was evaluated using human macrophages being not toxic at a concentration at least 8 times, and until 250 times, that of its T. cruzi IC50. Some biochemical pathways were studied, namely parasite respiration, ...