Tetrahedron letters

Chiral synthesis of L-γ-carboxyglutamic acid (L-Gla)

MA Schuerman, KI Keverline, RG Hiskey

文献索引：Tetrahedron Letters, , vol. 36, # 6 p. 825 - 828

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被引用次数: 8

摘要

... Tetrahedron Letters. Volume 36, Issue 6, 6 February 1995, Pages 825–828. ... A two step synthesis involving the use of a chiral template, benzyl (2R, 3S)-(−)6-oxo-2,3-diphenyl-4-morpholine- carboxylate 3 (5a), provides orthogonally protected L-Gla (9) in 60% overall yield (>99 ...