Tetrahedron letters

A practical synthesis of betulinic acid

R Csuk, K Schmuck, R Schäfer

文献索引：Csuk, Rene; Schmuck, Kianga; Schaefer, Renate Tetrahedron Letters, 2006 , vol. 47, # 49 p. 8769 - 8770

全文：HTML全文

被引用次数: 43

摘要

A new synthetic route for the synthesis of betulinic acid from betulin has been developed. The main step of this procedure is the selective oxidation of the primary alcohol function of betulin without affecting the secondary hydroxyl group. Applying shorter reaction times and lower temperatures results in the exclusive formation of the corresponding aldehyde, betulinal.