Efficient Aryl–(Hetero) Aryl Coupling by Activation of C Cl and C F Bonds Using Nickel Complexes of Air??Stable Phosphine Oxides

L Ackermann, R Born, JH Spatz…

文献索引：Ackermann, Lutz; Born, Robert; Spatz, Julia H.; Meyer, Daniel Angewandte Chemie - International Edition, 2005 , vol. 44, # 44 p. 7216 - 7219

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被引用次数: 192

摘要

Transition-metal-catalyzed cross-coupling reactions of organomagnesium compounds [1–4] are useful tools for the synthesis of unsymmetrically substituted biaryls, which are valuable building blocks for the synthesis of natural products, liquid crystals, polymers, and ligands.[5] Predominantly aryl iodides and bromides, and more recently aryl chlorides,[6] are employed as electrophiles. In contrast, the catalytic activation of unreactive CÀF bonds remains ...