Tetrahedron

An efficient Negishi cross-coupling reaction catalyzed by nickel (II) and diethyl phosphite

A Gavryushin, C Kofink, G Manolikakes, P Knochel

文献索引：Gavryushin, Andrei; Kofink, Christiane; Manolikakes, Georg; Knochel, Paul Tetrahedron, 2006 , vol. 62, # 32 p. 7521 - 7533

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被引用次数: 53

摘要

A combination of diethyl phosphite–DMAP and Ni (II) salts forms a very effective catalytic system for the cross-coupling reactions of arylzinc halides with aryl, heteroaryl, and alkenyl bromides, chlorides, triflates, and nonaflates. The choice of solvent is quite important and the mixture of THF–N-ethylpyrrolidinone (NEP)(8: 1) was found to be optimal. The reaction usually requires only 0.05 mol% of NiCl2 or Ni (acac) 2 as catalyst and proceeds at room ...