Synthesis of 2-(alkylamino)-5, 6-and-6, 7-dihydroxy-3, 4-dihydroquinazolines and evaluation as potential dopamine agonists

…, DE Nichols, JD Kohli, D Glock

文献索引：Grosso, John A.; Nichols, David E.; Kohli, Jai D.; Glock, Dana Journal of Medicinal Chemistry, 1982 , vol. 25, # 6 p. 703 - 708

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被引用次数: 33

摘要

Based upon the known dopaminergic properties of 2-aminodihydroxy-1, 2, 3, 4- tetrahydronaphthalenes(ADTN's), heterocyclic congeners were prepared. Several 2- (alkylamino)-5, 6-and-6, 7-dihydroxy-3, 4-dihydroquinazolines were synthesized and tested for a dopamine-like vasodilatory action in the canine renal artery. The 6, 7-disubstituted series had a weak antagonist effect against dopamine. Neither 5, 6-nor 6, 7-dihydroxy ...