Synthesis of N-substituted 3-nitrophthalimides

SI Zav'yalov, OV Dorofeeva, EE Rumyantseva…

文献索引：Zav'yalov; Dorofeeva; Rumyantseva; Kulikova; Ezhova; Kravchenko; Zavozin Pharmaceutical Chemistry Journal, 1998 , vol. 32, # 3 p. 154 - 156

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被引用次数: 1

摘要

The N-substituted 3-nitrophthalimides are known to pos- sess antibacterial [ 1], analgesic [2], and vasodilative [3] activ- ity. These compounds can be synthesized by heating 3-nitro- phthalic anhydride with amines either without solvent [4] or in acetic acid [5]. / Below we will show that N-substituted 3-Mitro- phthalimides are conveniently obtained by cyclocondensation of 3-nitrophthalic acid (I) with amines in the presence of a two-component reagent system CISiMe3- DMF. ...