Acrolein mercapturates: synthesis, characterization, and assessment of their role in the bladder toxicity of cyclophosphamide

K Ramu, LH Fraiser, B Mamiya, T Ahmed…

文献索引：Ramu; Fraiser; Mamiya; Ahmed; Kehrer Chemical Research in Toxicology, 1995 , vol. 8, # 4 p. 515 - 524

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被引用次数: 60

摘要

Acrolein is the metabolite of cyclophosphamide (CP) believed to be involved in the bladder toxicity associated with this anticancer drug. The mechanism by which this extremely reactive intermediate is delivered to the bladder is not known. Glutathione (GSH) readily conjugates with acrolein, and the acrolein mercapturate S-(3-hydroxypropyl)-N- acetylcysteine(3-hydroxy-PrMCA) has been found in the urine of animals and man given ...