Synthesis, antimalarial activity and cytotoxic potential of new monocarbonyl analogues of curcumin

S Manohar, SI Khan, SK Kandi, K Raj, G Sun…

文献索引：Manohar, Sunny; Khan, Shabana I.; Kandi, Shamseer Kulangara; Raj, Kranthi; Sun, Guojing; Yang, Xiaochuan; Calderon Molina, Angie D.; Ni, Nanting; Wang, Binghe; Rawat, Diwan S. Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 1 p. 112 - 116

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被引用次数: 32

摘要

A series of novel monocarbonyl analogues of curcumin have been designed, synthesized and tested for their activity against Molt4, HeLa, PC3, DU145 and KB cancer cell lines. Six of the analogues showed potent cytotoxicity towards these cell lines with IC50 values below 1μM, which is better than doxorubicin, a US FDA approved drug. Several analogues were also found to be active against both CQ-resistant (W2 clone) and CQ-sensitive (D6) strains ...